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Revolo Completes Enrollment of Phase 2 Trial in Eosinophilic Esophagitis

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Revolo Biotherapeutics (“Revolo” or the “Company”), a company developing therapies that reset the immune system to achieve superior long-term remission for patients with autoimmune and allergic diseases, today announced that it has completed enrollment and has fully randomized all patients in a Phase 2a proof of concept clinical study investigating its immune-resetting molecule, ‘1104, for the treatment of patients with eosinophilic esophagitis (EoE).

Jonathan Rigby, Group Chief Executive Officer of Revolo Biotherapeutics:

“We are pleased to announce the completion of enrollment in this trial, which comes ahead of our original expectations, enabling us to anticipate topline data around the end of the year. Given ’1104’s ability to reset the immune system from a pro inflammatory state to a regulated homeostatic state, we believe it has great potential to eliminate the debilitating symptoms that EoE patients suffer from.”

Evan Dellon, M.D., MPH, Gastroenterologist, Professor of Medicine and Adjunct Professor of Epidemiology at the University of North Carolina Chapel Hill, and Principal Investigator for the clinical trial, added, “Patients with EoE are very much in need of effective and safe therapies that treat this life-changing disease. This study will inform us about how ‘1104 affects histology and the associated inflammatory biomarkers, key components of the complex physiopathology of the disease.”

The Phase 2a, randomized, double-blind, placebo-controlled trial (NCT05084963) is designed to evaluate the safety and efficacy of ‘1104 in adults with EoE. Top line data is expected around the end of 2022.

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