Saturday, December 3, 2022


Biotechnology News Magazine

GlycoNet and Partners Invest $6.5 Million in Carbohydrate Research with One Health Focus

Latest Posts

Imago BioSciences Announces First Participant Dosed in Investigator-Sponsored Phase 1 Study of Bomedemstat in Combination with Venetoclax in Relapsed/Refractory Acute Myeloid Leukemia

Venetoclax is a BCL-2 inhibitor approved by the U.S. Food and Drug Administration (FDA) for treatment of several hematologic cancers, including in combination with azacytidine for elderly patients with AML unable to tolerate the standard of care.

Acer Therapeutics Announces $1.5M Private Placement

The proceeds from the private placement will be used by Acer Therapeutics for working capital and general corporate purposes and, together with Acer’s existing cash and cash equivalents, are expected to be sufficient to fund the Company’s anticipated operating and capital requirements through the fourth quarter of 2022.

AC Immune’s Alzheimer’s Disease Vaccine-candidate ACI-35.030 Selected for Further Development

Dr. Andrea Pfeifer, CEO of AC Immune SA, commented: “The selection of ACI-35.030 for further development is a significant step for this collaboration. Early clinical testing showed that ACI-35.030 was generally well tolerated and induced specific activity against the pathological species of Tau, including the neurotoxic pTau and enriched paired helical filaments (ePHF) species, both of which are closely implicated in Alzheimer’s disease (AD).

TransCode Therapeutics Announces eIND Submission to US FDA for Planned First-in-Human Clinical Trial in Patients with Advanced Solid Tumors

The planned clinical trial is to evaluate TransCode’s lead therapeutic candidate, TTX-MC138, in cancer patients with advanced solid tumors. ​TTX-MC138 is designed to inhibit the pro-metastatic RNA, microRNA-10b, described as the master regulator of metastasis in a number of advanced solid tumors. TransCode Therapeutics believes that TTX-MC138 could be used as a treatment for many of these cancers.

GlycoNet, one of the world’s leaders in glycomics research and discovery, announced a $2.46 million investment for 21 glycomics projects across Canada. Industry collaborators, health foundations and business partners are also co-investing $4 million, bringing the total funding to almost $6.5 million. This funding will support research critical to improving the health of humans, animals, and the environment.

“As the study of carbohydrates, known as glycomics, continues to rapidly improve our understanding of biological systems, our research and collaboration have grown to focus on One Health, which recognizes the interconnections among people, animals, and the environment,” says Elizabeth Nanak, CEO, GlycoNet. “Our funding will further the development of made-in-Canada health solutions while building a sustainable, diverse bioeconomy, through advancing Canadian glycomics research, commercialization, and training of top talent.”

One of the funded initiatives is advancing a carbohydrate-based “cage” technology that enables anti-inflammatory drugs to be delivered more efficiently to the lower gastrointestinal tract, reducing the potential for side effects. Dr. Harry Brumer at the University of British Columbia is leading the team developing this technology, which could be used to improve the treatment of lower gut diseases such as inflammatory bowel disease—a condition that affects 300,000 Canadians (Crohn’s and Colitis Canada).

“Support from GlycoNet and other partners has been invaluable to enable us to build a diverse team of chemists, microbiologists, and clinical scientists across different provinces to accelerate technology development toward translation,” says Brumer.

Further, the announced funding will support a project set to develop a carbohydrate-based vaccine to protect pigs against the infection caused byStreptococcus suis, a common cause of severe disease and death in piglets. Dr. Mariela Segura, who is leading the project at the University of Montreal, anticipates that the vaccine will provide an alternative to the use of antimicrobials, helping combat the growing challenge of antimicrobial resistance, while also supporting the Canadian economy. Across the country, more than 7,000 pig farms contribute to the creation of tens of thousands of jobs and a resulting economic output of $23.8 billion (Canadian Pork Council).

This investment is also funding research to develop innovative biomarkers for measuring the health status of ocean food resources in the context of climate change. The research led by Dr. Yves St-Pierre at Institut national de la recherche scientifique involves integrating our knowledge of carbohydrates in biological processes to enhance the analysis of samples collected from mussels and fish.

“With climate change putting continuous pressure on marine resources, it is increasingly important that we have sensitive and predictive biomarkers to help with routine monitoring of marine resources,” says St-Pierre. “Changes in the health of ocean food sources have profound impacts in terms of food safety, as well as economical and social consequences for local fishing communities or northern communities.”

Mobilizing knowledge, expertise and collaborations in the study of carbohydrates opens new doors to understanding the relationships that underpin human, animal and environmental health. This funding will enable researchers to develop made-in-Canada One Health solutions, while also yielding the creation of new companies, jobs and economic growth.

Quick Facts

  • Glycomics is the study of carbohydrates or sugars (called glycans) in all living organisms.
  • Today’s announcement is for $2.46 million in funding for glycomics research plus $4 million in co-funding from research partners and industry collaborators across Canada.
  • Since 2015, GlycoNet has invested $32 million from the federal Network of Centres of Excellence program and leveraged $39 million of partner funding into R&D, trained over 590 highly qualified personnel and has supported the start-up of 5 new Canadian companies.

Learn more here about the projects receiving funding.

Latest Posts

Learn More




Our Sister Publication

Medical Device News Magazine