Tuesday, October 4, 2022

561.316.3330

Biotechnology News Magazine

1st Patient Dosed in Phase 1b/2 Clinical Trial of Lanraplenib in Combination with Gilteritinib in Acute Myeloid Leukemia

Latest Posts

BRAINBox Solutions Announces New U.S. Patent Allowance, Strengthening Biomarker Portfolio for Multi-Modal Mild Traumatic Brain Injury Test

BRAINBox Solutions notes the new patent covers both diagnosis of TBI and patient monitoring post-injury, particularly for determining return to work or play.

New Initiative Brings Leading Life Sciences Companies Together To Drive Collective Impact in Awareness, Diagnosis, Care, and Health Equity for Patients with Amyloidosis

Despite notable progress in recent years, amyloidosis patients continue to experience high unmet needs and gaps in treatment and support.

GBS Inc. Acquires Intelligent Fingerprinting Limited and its Proprietary Drugs of Abuse Screening Technology

Steven Boyages, CEO of GBS Inc. stated, “We believe this acquisition generates significant value for our shareholders, and I am extremely excited to be on the forefront of this transition. Bringing IFP under the GBS umbrella marks a significant advancement toward achieving our strategic goals of improving patients’ lives outside of saliva-based glucose testing and laying the pathway in becoming a leader in the development of rapid, non-invasive diagnostic solutions. We remain excited to accelerate our strategy and revenue growth through this collaboration with IFP.”

Araris Biotech Closes $24 Million Financing Round

Araris Biotech notes the proceeds from the financing will be used to support the further development and advancement of Araris’ antibody-drug conjugate (ADC) candidates, created using the Company’s proprietary linker technology, as Araris moves closer toward clinical development.

Kronos Bio, Inc. (Nasdaq: KRON), a company dedicated to transforming the lives of those affected by cancer, today announced that the first patient has been dosed in a Phase 1b/2 clinical trial of lanraplenib in combination with gilteritinib in patients with relapsed/refractory FLT3-mutated acute myeloid leukemia (AML).

Lanraplenib is the company’s next-generation spleen tyrosine kinase (SYK) inhibitor. In addition to lanraplenib, Kronos Bio is also evaluating its lead investigational SYK inhibitor, entospletinib, in the Phase 3 registrational AGILITY study as a treatment for newly diagnosed patients with NPM1-mutated AML in combination with standard induction and consolidation chemotherapy. While entospletinib and lanraplenib have equivalent preclinical anti-leukemic activity and selectivity for SYK, lanraplenib’s pharmacologic properties may be advantageous in regimens that are dosed to progression, such as the investigational gilteritinib combination.

The Phase 1b/2 lanraplenib clinical trial is a multi-center, open-label, dose-escalation study enrolling patients with relapsed/refractory FLT3-mutated AML. This trial is being conducted in two stages: a dose-escalation stage and an expansion stage. The first stage is evaluating initial safety, pharmacokinetic and anti-leukemic activity of escalating once-daily doses of lanraplenib in combination with the standard approved dose of gilteritinib. This stage also will assess FLT3 measurable residual disease (MRD) negative rate in patients who achieve a complete response (CR) and explore the predictive value of a number of biomarkers that may correlate with clinical outcomes.

Once a recommended dose is established, an expansion stage is planned to further evaluate the safety of lanraplenib and assess its anti-leukemic activity as measured by CR rate and duration of response.

“The initiation of this study is an important first step as we advance lanraplenib for patients with certain genetically defined types of AML,” said Jorge DiMartino, M.D., Ph.D., chief medical officer and executive vice president of Clinical Development at Kronos Bio. “Our long-term vision is to develop lanraplenib as a cornerstone of targeted regimens for these patients, allowing us to potentially reach as many as two-thirds of patients with AML. Today’s announcement represents important progress toward that goal.”

Kronos Bio currently has three investigational compounds in clinical development. In addition to the SYK inhibitors, which were acquired from Gilead Sciences, Inc., the company is advancing KB-0742, a highly selective, orally bioavailable inhibitor of cyclin dependent kinase 9 (CDK9) as a treatment for MYC-amplified solid tumors. KB-0742 is currently being studied in a Phase 1/2 trial and is the first compound discovered through the company’s proprietary small molecule microarray (SMM) screening platform.

Learn more about Krono Bio’s clinical trials here.

Latest Posts

Learn More

spot_img

Subscribe

spot_img

Our Sister Publication

Medical Device News Magazine