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New Quality of Life Data for Valtoco (Diazepam Nasal Spray)CIV in the Treatment of Seizure Clusters Published in Epilepsy & Behavior

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  • Seventy-two of 85 adult patients with seizure clusters who were enrolled in the long-term, Phase 3, open-label clinical trial of VALTOCO® (diazepam nasal spray) reported stable or increased Quality of Life (QoL) during the study, according to recent findings published online in the leading journal, Epilepsy & Behavior.

“Caregivers and patients with seizure clusters worry about when the next seizure is going to happen,” said Adrian Rabinowicz, MD, SVP Clinical Development and Medical Affairs. “These findings indicate that if we can reduce the number of seizure clusters with acute, rapid therapies, we potentially can have an impact on both seizure worry and social functioning.”

Until now, limited research has been conducted to assess QoL as a potential secondary endpoint in patients with seizure clusters. The 12-month study of diazepam nasal spray enrolled patients 6-to-65 years with seizure clusters. Adults ≥18 years completed the Quality of Life in Epilepsy (QOLIE)-31-P at baseline (day 0) and days 30, 150, 270, and 365. Participants answered questions about their health and daily activities, and responses were assigned numeric values (1-100). Higher scores indicated better QoL.

“These findings suggest the need for further study of the impact of acute, rapid therapies on QoL in this patient population,” said Sunita Misra, MD, Senior Medical Director at Neurelis. “Patients and caregivers need to feel empowered by a treatment plan that may reduce their seizure clusters while potentially improving their overall quality of life.”

QoL measures included seizure worry, overall QoL, emotional wellbeing, energy/fatigue, cognitive functioning, medication effects, and social functioning.

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