Monday, October 3, 2022


Biotechnology News Magazine

U-Load Dextramer ® with Peptide Receptive MHC I and MHC II Monomers Greatly Expands Flexibility while Ensuring Reliable Sensitivity in Exploring Diversity of Cellular Immune Responses

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U-Load Dextramer ® Immudex announces the launch of the new U-Load Dextramer® product line that allows scientists to swiftly assemble their own sensitive antigen-specific Dextramer® reagents for immune monitoring directly in the lab using loadable MHC class I easYmer® and the novel loadable MHC class II monomers, U-Load MHC II.

Whether via flow cytometry or next-generation sequencing, U-Load Dextramer® product portfolio will allow scientists and clinicians worldwide to create fit-for-purpose immune monitoring reagents from the comfort of their lab while giving them access to the broadest human allele coverage on the loadable market for both MHC I and MHC II.

“Our R&D team has developed this new technology while keeping the needs of the customer in mind,” says Henrik Martin Pfundheller, ‘Immudex’ CCO. “The fast and easy protocol, the broad allele coverage, and the ability to create sensitive Dextramer® reagents in just 1 hour, clearly offer our customers a truly plug-and-play solution; all they need to do is adding their peptide of choice.”

This launch is the result of the previously announced partnership with immunAware. Immudex is now the proud global distributor of the high-quality easYmer® MHC monomers. Covering a large spectrum (+40) of HLA-A, HLA-B, and HLA-C allotypes found in many world populations, these monomers allow the creation of specific peptide-allele combinations suitable for epitope and neoantigen screening, mapping of antigen-specific T-cell responses to disease(s), and assessment of peptide-MHC binding.

easYmer® and U-Load MHC II monomers serve as the building blocks of U-Load Dextramer® and U-Load dCODE Dextramer® reagents, allowing scientists and researchers to implement the benefits of the Dextramer® technology in any project.

“Fast-moving fields like immune-oncology and vaccine development crave to understand the specific immunological response in detail and at scale,” says Liselotte Brix, CSO at Immudex. “That is why we also have developed the U-Load dCODE Dextramer®. The flexible engineering of U-Load dCODE Dextramer® unifies the “plug-and-play” architecture of U-Load Dextramer® with the unique DNA barcode labels of dCODE®. It is designed for next-generation sequencing and single-cell multi-omics analysis, and we have made them compatible with BD Rhapsody™ Single-Cell Analysis System (BD Biosciences) and 10x Chromium Single Cell Gene Expression (10x Genomics).

U-Load products are available for a range of throughput needs.

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